Role for combined use of amantadine hydrochloride and influenza immunization.
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Through a multisite, prospective, double-blind, randomized, placebo-controlled trial, this study aimed to 1 determine if the single-site results were reproducible; 2 assess the generalizability to different regions and centers; 3 determine if the amantadine irritability effect persisted over 60 days; and 4 evaluate participant and clinician impressions of effect.
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The literature suggests that amantadine initiated within 12 weeks of tbi, may improve cognition and reduce agitation.
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